성주헌

학력

서울대학교 의학과, 학사, 1993
서울대학교 보건대학원, 보건학, 석사, 1998
서울대학교 의학대학원, 예방의학, 박사, 2000
Southwest Foundation for Biomedical Research, 유전역학, Postdoc, 2004
Columbia University, 유전역학, Postdoc, 2005
 

연구분야

유전체역학, 유전체코호트, 가족 및 쌍둥이 연구
비만-대사질환 및 심혈관계질환 가족암등록

 

연구실적

You HJ, Si J, Kim J, et al. Bacteroides vulgatus SNUG 40005 Restores Akkermansia Depletion by Metabolite Modulation. Gastroenterology. Jan 2023;164(1):103-116. doi:10.1053/j.gastro.2022.09.040

Silventoinen K, Piirtola M, Jelenkovic A, et al. Smoking remains associated with education after controlling for social background and genetic factors in a study of 18 twin cohorts. Sci Rep. Jul 31 2022;12(1):13148. doi:10.1038/s41598-022-17536-x

Nguyen TL, Li S, Dowty JG, et al. Familial Aspects of Mammographic Density Measures Associated with Breast Cancer Risk. Cancers (Basel). Mar 14 2022;14(6)doi:10.3390/cancers14061483

Li S, Nguyen TL, Nguyen-Dumont T, et al. Genetic Aspects of Mammographic Density Measures Associated with Breast Cancer Risk. Cancers (Basel). Jun 2 2022;14(11)doi:10.3390/cancers14112767

Lee KJ, Lee SJ, Bae HJ, Sung J. Exploring the causal inference of migraine on stroke: A Mendelian randomization study. Eur J Neurol. Jan 2022;29(1):335-338. doi:10.1111/ene.15101

Lee EJ, Sung J, Kim HL, Kim HN. Whole-Genome Sequencing Reveals Age-Specific Changes in the Human Blood Microbiota. J Pers Med. Jun 7 2022;12(6)doi:10.3390/jpm12060939

Kim YS, Kang M, Choe YJ, Sung J, Lee JY, Choe SA. Child mortality of twins and singletons among late preterm and term birth: a study of national linked birth and under-five mortality data of Korea. Eur J Pediatr. May 2022;181(5):2109-2116. doi:10.1007/s00431-022-04410-1

Kim M, Sung J, Kim JK, et al. Multiple primary cancers in men with sporadic or familial prostate cancer: Its clinical implications. Urol Oncol. Nov 2022;40(11):489.e1-489.e7. doi:10.1016/j.urolonc.2022.07.016

Kim HJ, Son HY, Sung J, et al. A Genome-Wide Association Study on Abdominal Adiposity-Related Traits in Adult Korean Men. Obes Facts. 2022;15(4):590-599. doi:10.1159/000524670

Kang GW, Kim YH, Hong C, et al. Heritability of maxillary dental cephalometric variables among monozygotic twins, dizygotic twins and their siblings. Clin Oral Investig. Oct 2022;26(10):6275-6281. doi:10.1007/s00784-022-04579-7

Jeong Y, Sung J. An automated deep learning method and novel cardiac index to detect canine cardiomegaly from simple radiography. Sci Rep. Aug 25 2022;12(1):14494. doi:10.1038/s41598-022-18822-4

Jeong Y, Cho CE, Kim JE, et al. Deep learning model to predict Epstein-Barr virus associated gastric cancer in histology. Sci Rep. Nov 2 2022;12(1):18466. doi:10.1038/s41598-022-22731-x

Zwir I, Del-Val C, Arnedo J, et al. Three genetic-environmental networks for human personality. Mol Psychiatry. Aug 2021;26(8):3858-3875. doi:10.1038/s41380-019-0579-x

Seki M, Choi H, Kim K, Whang J, Sung J, Mitarai S. Tuberculosis: A persistent unpleasant neighbour of humans. J Infect Public Health. Apr 2021;14(4):508-513. doi:10.1016/j.jiph.2021.01.005

Park HM, Kim PJ, Sung J, et al. Differences in the heritability of craniofacial skeletal and dental characteristics between twin pairs with skeletal Class I and II malocclusions. Korean J Orthod. Nov 25 2021;51(6):407-418. doi:10.4041/kjod.2021.51.6.407

Nguyen TL, Schmidt DF, Makalic E, et al. Novel mammogram-based measures improve breast cancer risk prediction beyond an established mammographic density measure. Int J Cancer. May 1 2021;148(9):2193-2202. doi:10.1002/ijc.33396

Kong M, Hwang S, Ko H, et al. Heritability of macular ganglion cell inner plexiform layer thickness as determined by optical coherence tomography: the Healthy Twin Study. Br J Ophthalmol. Jul 2021;105(7):1011-1015. doi:10.1136/bjophthalmol-2020-316512

Kim H, Choe SA, Lee SJ, Sung J. Causal relationship between the timing of menarche and young adult body mass index with consideration to a trend of consistently decreasing age at menarche. PLoS One. 2021;16(2):e0247757. doi:10.1371/journal.pone.0247757

Kim H, Bae JH, Park KS, Sung J, Kwak SH. DNA Methylation Changes Associated with Type 2 Diabetes and Diabetic Kidney Disease in an East Asian Population. J Clin Endocrinol Metab. Jul 2 2021;doi:10.1210/clinem/dgab488

Joo Kang S, Shin CM, Sung J, Kim N. Association Between ALDH2 Polymorphism and Gastric Cancer Risk in Terms of Alcohol Consumption: A Meta-Analysis. Alcohol Clin Exp Res. Jan 2021;45(1):6-14. doi:10.1111/acer.14508

Jokkel Z, Forgo B, Hani-Gaius Ghattas C, et al. Heritability of Cardiothoracic Ratio and Aortic Arch Calcification in Twins. Medicina (Kaunas). Apr 27 2021;57(5)doi:10.3390/medicina57050421

Cho J, Park K, Choi SM, et al. Genome-wide association study of non-tuberculous mycobacterial pulmonary disease. Thorax. Feb 2021;76(2):169-177. doi:10.1136/thoraxjnl-2019-214430

Zwir I, Arnedo J, Del-Val C, et al. Uncovering the complex genetics of human temperament. Mol Psychiatry. Oct 2020;25(10):2275-2294. doi:10.1038/s41380-018-0264-5

Zwir I, Arnedo J, Del-Val C, et al. Uncovering the complex genetics of human character. Mol Psychiatry. Oct 2020;25(10):2295-2312. doi:10.1038/s41380-018-0263-6

Song DY, Youn J, Kim K, Sung J, Lee JE. Urinary Sodium and Potassium Levels and Blood Pressure in Population with High Sodium Intake. Nutrients. Nov 10 2020;12(11)doi:10.3390/nu12113442

Silventoinen K, Jelenkovic A, Sund R, et al. Genetic and environmental variation in educational attainment: an individual-based analysis of 28 twin cohorts. Sci Rep. Jul 29 2020;10(1):12681. doi:10.1038/s41598-020-69526-6

Seo B, Jeon K, Moon S, et al. Roseburia spp. Abundance Associates with Alcohol Consumption in Humans and Its Administration Ameliorates Alcoholic Fatty Liver in Mice. Cell Host Microbe. Jan 8 2020;27(1):25-40.e6. doi:10.1016/j.chom.2019.11.001

Oh JJ, Shivakumar M, Miller J, et al. Author Correction: An exome-wide rare variant analysis of Korean men identifies three novel genes predisposing to prostate cancer. Sci Rep. Feb 7 2020;10(1):2481. doi:10.1038/s41598-020-59361-0

Nguyen TL, Schmidt DF, Makalic E, et al. Novel mammogram-based measures improve breast cancer risk prediction beyond an established mammographic density measure. Int J Cancer. Nov 16 2020;doi:10.1002/ijc.33396

Nguyen TL, Li S, Dite GS, et al. Interval breast cancer risk associations with breast density, family history and breast tissue aging. Int J Cancer. Jul 15 2020;147(2):375-382. doi:10.1002/ijc.32731

Mukasa D, Sung J. A prediction model of Nephrolithiasis Risk: A population-based cohort study in Korea. Investig Clin Urol. Mar 2020;61(2):188-199. doi:10.4111/icu.2020.61.2.188

Mukasa D, Sung J. A prediction model of low back pain risk: a population based cohort study in Korea. Korean J Pain. Apr 1 2020;33(2):153-165. doi:10.3344/kjp.2020.33.2.153

Meszaros M, Tarnoki AD, Tarnoki DL, et al. Obstructive sleep apnea and hypertriglyceridaemia share common genetic background: Results of a twin study. J Sleep Res. Jan 6 2020:e12979. doi:10.1111/jsr.12979

Li S, Nguyen TL, Wong EM, et al. Genetic and environmental causes of variation in epigenetic aging across the lifespan. Clin Epigenetics. Oct 22 2020;12(1):158. doi:10.1186/s13148-020-00950-1

Kong M, Hwang S, Ko H, et al. Heritability of macular ganglion cell inner plexiform layer thickness as determined by optical coherence tomography: the Healthy Twin Study. Br J Ophthalmol. Aug 11 2020;doi:10.1136/bjophthalmol-2020-316512

Kim JH, Kim YH, Kim SJ, et al. Twin study-genetic comparison of matrix versus intramatrix rotation in the mandible and three different occlusal planes. Prog Orthod. Dec 7 2020;21(1):44. doi:10.1186/s40510-020-00344-2

Kim J, Sung J, Han K, et al. A High Quality Asian Genome Assembly Identifies Features of Common Missing Regions. Genes (Basel). Nov 13 2020;11(11)doi:10.3390/genes11111350

Kim J, Lee J, Choi IJ, Kim YI, Sung J, Kim J. TNF genetic polymorphism (rs1799964) may modify the effect of the dietary inflammatory index on gastric cancer in a case-control study. Sci Rep. Sep 3 2020;10(1):14590. doi:10.1038/s41598-020-71433-9

Kim HJ, Seo YS, Sung J, et al. A genome-wide by PM10 interaction study identifies novel loci for lung function near BICD1 and IL1RN-IL1F10 genes in Korean adults. Chemosphere. Apr 2020;245:125581. doi:10.1016/j.chemosphere.2019.125581

Kim AN, Cho HJ, Youn J, et al. Coffee Consumption, Genetic Polymorphisms, and the Risk of Type 2 Diabetes Mellitus: A Pooled Analysis of Four Prospective Cohort Studies. Int J Environ Res Public Health. Jul 26 2020;17(15)doi:10.3390/ijerph17155379

Kho M, Smith JA, Verweij N, et al. Genome-Wide Association Meta-Analysis of Individuals of European Ancestry Identifies Suggestive Loci for Sodium Intake, Potassium Intake, and Their Ratio Measured from 24-Hour or Half-Day Urine Samples. J Nutr. Oct 12 2020;150(10):2635-2645. doi:10.1093/jn/nxaa241

Jin T, Youn J, Kim AN, et al. Interactions of Habitual Coffee Consumption by Genetic Polymorphisms with the Risk of Prediabetes and Type 2 Diabetes Combined. Nutrients. Jul 26 2020;12(8)doi:10.3390/nu12082228

Jelenkovic A, Sund R, Yokoyama Y, et al. Genetic and environmental influences on human height from infancy through adulthood at different levels of parental education. Sci Rep. May 14 2020;10(1):7974. doi:10.1038/s41598-020-64883-8

Hopper JL, Nguyen TL, Schmidt DF, et al. Going Beyond Conventional Mammographic Density to Discover Novel Mammogram-Based Predictors of Breast Cancer Risk. J Clin Med. Feb 26 2020;9(3)doi:10.3390/jcm9030627

Gim J, An J, Sung J, Silverman EK, Cho MH, Won S. A Between Ethnicities Comparison of Chronic Obstructive Pulmonary Disease Genetic Risk. Front Genet. 2020;11:329. doi:10.3389/fgene.2020.00329

Choe SA, Sung J. Trends of Premature and Early Menopause: a Comparative Study of the US National Health and Nutrition Examination Survey and the Korea National Health and Nutrition Examination Survey. J Korean Med Sci. Apr 13 2020;35(14):e97. doi:10.3346/jkms.2020.35.e97

Cho J, Park K, Choi SM, et al. Genome-wide association study of non-tuberculous mycobacterial pulmonary disease. Thorax. Oct 28 2020;doi:10.1136/thoraxjnl-2019-214430

Zwir I, Del-Val C, Arnedo J, et al. Three genetic-environmental networks for human personality. Mol Psychiatry. Nov 21 2019;doi:10.1038/s41380-019-0579-x

Szily M, Tarnoki AD, Tarnoki DL, et al. Genetic influences on the onset of obstructive sleep apnoea and daytime sleepiness: a twin study. Respir Res. Jun 17 2019;20(1):125. doi:10.1186/s12931-019-1095-x

Song YM, Lee K, Sung J. Genetic and environmental relationships between eating behavior and symptoms of anxiety and depression. Eat Weight Disord. Oct 2019;24(5):887-895. doi:10.1007/s40519-017-0445-2

Song J, Chae HS, Shin JW, et al. Influence of heritability on craniofacial soft tissue characteristics of monozygotic twins, dizygotic twins, and their siblings using Falconer's method and principal components analysis. Korean J Orthod. Jan 2019;49(1):3-11. doi:10.4041/kjod.2019.49.1.3

Silventoinen K, Jelenkovic A, Latvala A, et al. Parental Education and Genetics of BMI from Infancy to Old Age: A Pooled Analysis of 29 Twin Cohorts. Obesity (Silver Spring). May 2019;27(5):855-865. doi:10.1002/oby.22451

Oh JJ, Shivakumar M, Miller J, et al. An exome-wide rare variant analysis of Korean men identifies three novel genes predisposing to prostate cancer. Sci Rep. Nov 20 2019;9(1):17173. doi:10.1038/s41598-019-53445-2

Oh B, Sung J, Chun S. Potentially modifiable blood triglyceride levels by the control of conventional risk factors. Lipids Health Dis. Dec 13 2019;18(1):222. doi:10.1186/s12944-019-1134-0

Nguyen TL, Li S, Dite GS, et al. Interval breast cancer risk associations with breast density, family history and breast tissue aging. Int J Cancer. Oct 14 2019;doi:10.1002/ijc.32731

Lee SJ, Lee JY, Sung J. Obesity and Bone Health Revisited: A Mendelian Randomization Study for Koreans. J Bone Miner Res. Jun 2019;34(6):1058-1067. doi:10.1002/jbmr.3678

Kim HJ, Seo YS, Sung J, et al. Interactions of CDH13 gene polymorphisms and ambient PM10 air pollution exposure with blood pressure and hypertension in Korean men. Chemosphere. Mar 2019;218:292-298. doi:10.1016/j.chemosphere.2018.11.125

Kim DK, Sung J, Song YM, Kim EM, Kim YH, Baek SH. Differences in heritability of craniofacial skeletal and dental characteristics between hypo- and hyper-divergent patterns using Falconer's method and principal component analysis. Angle Orthod. Mar 2019;89(2):242-251. doi:10.2319/062518-475.1

Kang M, Sung J. A genome-wide search for gene-by-obesity interaction loci of dyslipidemia in Koreans shows diverse genetic risk alleles. J Lipid Res. Dec 2019;60(12):2090-2101. doi:10.1194/jlr.P119000226

Chauhan G, Adams HHH, Satizabal CL, et al. Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting. Neurology. Jan 16 2019;doi:10.1212/wnl.0000000000006851

Zwir I, Arnedo J, Del-Val C, et al. Uncovering the complex genetics of human temperament. Mol Psychiatry. Oct 2 2018;doi:10.1038/s41380-018-0264-5

Zwir I, Arnedo J, Del-Val C, et al. Uncovering the complex genetics of human character. Mol Psychiatry. Oct 3 2018;doi:10.1038/s41380-018-0263-6

Yang S, Lee J, Park Y, et al. Interaction between alcohol consumption and methylenetetrahydrofolate reductase polymorphisms in thyroid cancer risk: National Cancer Center cohort in Korea. Sci Rep. Mar 6 2018;8(1):4077. doi:10.1038/s41598-018-22189-w

Wyss AB, Sofer T, Lee MK, et al. Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function. Nat Commun. Jul 30 2018;9(1):2976. doi:10.1038/s41467-018-05369-0

Shin CM, Kim N, Cho SI, Sung J, Lee HJ. Validation of Alcohol Flushing Questionnaires in Determining Inactive Aldehyde Dehydrogenase-2 and Its Clinical Implication in Alcohol-Related Diseases. Alcohol Clin Exp Res. Feb 2018;42(2):387-396. doi:10.1111/acer.13569

Piirtola M, Jelenkovic A, Latvala A, et al. Association of current and former smoking with body mass index: A study of smoking discordant twin pairs from 21 twin cohorts. PLoS One. 2018;13(7):e0200140. doi:10.1371/journal.pone.0200140

Park B, Koo SM, An J, et al. Genome-wide assessment of gene-by-smoking interactions in COPD. Sci Rep. Jun 18 2018;8(1):9319. doi:10.1038/s41598-018-27463-5

Nguyen TL, Choi YH, Aung YK, et al. Breast Cancer Risk Associations with Digital Mammographic Density by Pixel Brightness Threshold and Mammographic System. Radiology. Feb 2018;286(2):433-442. doi:10.1148/radiol.2017170306

Nguyen TL, Aung YK, Li S, et al. Predicting interval and screen-detected breast cancers from mammographic density defined by different brightness thresholds. Breast Cancer Res. Dec 13 2018;20(1):152. doi:10.1186/s13058-018-1081-0

Li S, Wong EM, Dugue PA, et al. Genome-wide average DNA methylation is determined in utero. Int J Epidemiol. Jun 1 2018;47(3):908-916. doi:10.1093/ije/dyy028

Lee JY, Kim J, Kim SW, et al. BRCA1/2-negative, high-risk breast cancers (BRCAX) for Asian women: genetic susceptibility loci and their potential impacts. Sci Rep. Oct 15 2018;8(1):15263. doi:10.1038/s41598-018-31859-8

Lee DW, Cho MS, Choe EY, et al. Epicardial Fat Thickness and Bone Mineral Content: The Healthy Twin Study in Korea. J Epidemiol. May 5 2018;28(5):253-259. doi:10.2188/jea.JE20170027

Kong M, Choi DY, Han G, et al. Measurable Range of Subfoveal Choroidal Thickness With Conventional Spectral Domain Optical Coherence Tomography. Transl Vis Sci Technol. Sep 2018;7(5):16. doi:10.1167/tvst.7.5.16

Ko H, Song YM, Lee SC, et al. Association Between Excessive Alcohol Consumption and Echocardiographic Parameters According to the Presence of Flushing Reaction in Korean Men: A Community-Based Study. Alcohol Clin Exp Res. May 2018;42(5):897-903. doi:10.1111/acer.13622

Kim JH, Yeo S, Kim JW, et al. Real-Time Lossless Compression Algorithm for Ultrasound Data Using BL Universal Code. Sensors (Basel). Oct 2 2018;18(10)doi:10.3390/s18103314

Kim I, Song YM, Ko H, et al. Educational Disparities in Risk for Metabolic Syndrome. Metab Syndr Relat Disord. Oct 2018;16(8):416-424. doi:10.1089/met.2017.0170

Kim HJ, Park JH, Seo YS, et al. CYP1A1 gene polymorphisms modify the association between PM10 exposure and lung function. Chemosphere. Jul 2018;203:353-359. doi:10.1016/j.chemosphere.2018.03.196

Kim E, Sung J, Song YM, et al. Heritability of Facial Skeletal and Dental Characteristics of Monozygotic and Dizygotic Twins Using Cephalometric Analysis and Falconer's Method. J Craniofac Surg. May 2018;29(3):e274-e279. doi:10.1097/scs.0000000000004313

Jelenkovic A, Yokoyama Y, Sund R, et al. Associations between birth size and later height from infancy through adulthood: An individual based pooled analysis of 28 twin cohorts participating in the CODATwins project. Early Hum Dev. May 2018;120:53-60. doi:10.1016/j.earlhumdev.2018.04.004

Jelenkovic A, Mikkonen J, Martikainen P, et al. Association between birth weight and educational attainment: an individual-based pooled analysis of nine twin cohorts. J Epidemiol Community Health. Sep 2018;72(9):832-837. doi:10.1136/jech-2017-210403

Choi S, Ko H, Lee K, Sung J, Song YM. Genetic influence on serum 25-hydroxyvitamin D concentration in Korean men: a cross-sectional study. Genes Nutr. 2018;13:33. doi:10.1186/s12263-018-0621-7

Cho Y, Lee S, Hong JH, et al. Development of the variant calling algorithm, ADIScan, and its use to estimate discordant sequences between monozygotic twins. Nucleic Acids Res. Sep 6 2018;46(15):e92. doi:10.1093/nar/gky445